ITO is mainly used in the production of liquid crystal display, flat panel display, plasma display, touch screen, electronic paper, organic light-emitting diode, as well as solar cells, and anti-static coating and EMI shielding transparent conduction coating.

ITO is also used in a variety of optical coatings, most notably in architecture with infrared-reflection coatings (thermal mirrors), automobiles, and sodium vapor lamp glass. Other applications include gas sensors, anti-reflection membranes, and Bragg reflectors for VCSEL lasers.

ITO film stress gauges can be used in harsh environments above 1400°C, such as gas turbines, jet engines, and rocket engines.